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(A) Example behavioral and neural recordings during 50 Hz stimulation (arousal score 5). (B) Population mean arousal score (±SE) before, during and after stimulations for both monkeys (circles show individual stimulation events). (C) Coronal section of right hemisphere 8mm anterior to interaural line (A8). Arrow shows electrode. (D) Zoomed-in view of thalamus. (E) Stimulation sites in monkey R (N = 90) collapsed along A-P axis. Circles represent middle contact in stimulation array; diameter scales with induced arousal. (F) Stimulation-induced arousal change (score during stim – pre) as function of dorsal-ventral distance from CL center. Symbols show stimulation events by monkey; red curve shows quadratic fit (±SE). (G) Example stimulation series for different frequencies during <t>propofol</t> (left) and isoflurane (right) at same site 22.5 mm ventral to cortical surface. (H) Population mean arousal change (±SE of point estimate) for different stimulation frequencies at effective and ineffective sites from both monkeys.
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(A) Example behavioral and neural recordings during 50 Hz stimulation (arousal score 5). (B) Population mean arousal score (±SE) before, during and after stimulations for both monkeys (circles show individual stimulation events). (C) Coronal section of right hemisphere 8mm anterior to interaural line (A8). Arrow shows electrode. (D) Zoomed-in view of thalamus. (E) Stimulation sites in monkey R (N = 90) collapsed along A-P axis. Circles represent middle contact in stimulation array; diameter scales with induced arousal. (F) Stimulation-induced arousal change (score during stim – pre) as function of dorsal-ventral distance from CL center. Symbols show stimulation events by monkey; red curve shows quadratic fit (±SE). (G) Example stimulation series for different frequencies during <t>propofol</t> (left) and isoflurane (right) at same site 22.5 mm ventral to cortical surface. (H) Population mean arousal change (±SE of point estimate) for different stimulation frequencies at effective and ineffective sites from both monkeys.
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(A) Example behavioral and neural recordings during 50 Hz stimulation (arousal score 5). (B) Population mean arousal score (±SE) before, during and after stimulations for both monkeys (circles show individual stimulation events). (C) Coronal section of right hemisphere 8mm anterior to interaural line (A8). Arrow shows electrode. (D) Zoomed-in view of thalamus. (E) Stimulation sites in monkey R (N = 90) collapsed along A-P axis. Circles represent middle contact in stimulation array; diameter scales with induced arousal. (F) Stimulation-induced arousal change (score during stim – pre) as function of dorsal-ventral distance from CL center. Symbols show stimulation events by monkey; red curve shows quadratic fit (±SE). (G) Example stimulation series for different frequencies during <t>propofol</t> (left) and isoflurane (right) at same site 22.5 mm ventral to cortical surface. (H) Population mean arousal change (±SE of point estimate) for different stimulation frequencies at effective and ineffective sites from both monkeys.
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Image Search Results


(A) Example behavioral and neural recordings during 50 Hz stimulation (arousal score 5). (B) Population mean arousal score (±SE) before, during and after stimulations for both monkeys (circles show individual stimulation events). (C) Coronal section of right hemisphere 8mm anterior to interaural line (A8). Arrow shows electrode. (D) Zoomed-in view of thalamus. (E) Stimulation sites in monkey R (N = 90) collapsed along A-P axis. Circles represent middle contact in stimulation array; diameter scales with induced arousal. (F) Stimulation-induced arousal change (score during stim – pre) as function of dorsal-ventral distance from CL center. Symbols show stimulation events by monkey; red curve shows quadratic fit (±SE). (G) Example stimulation series for different frequencies during propofol (left) and isoflurane (right) at same site 22.5 mm ventral to cortical surface. (H) Population mean arousal change (±SE of point estimate) for different stimulation frequencies at effective and ineffective sites from both monkeys.

Journal: Neuron

Article Title: Thalamus modulates consciousness via layer-specific control of cortex

doi: 10.1016/j.neuron.2020.01.005

Figure Lengend Snippet: (A) Example behavioral and neural recordings during 50 Hz stimulation (arousal score 5). (B) Population mean arousal score (±SE) before, during and after stimulations for both monkeys (circles show individual stimulation events). (C) Coronal section of right hemisphere 8mm anterior to interaural line (A8). Arrow shows electrode. (D) Zoomed-in view of thalamus. (E) Stimulation sites in monkey R (N = 90) collapsed along A-P axis. Circles represent middle contact in stimulation array; diameter scales with induced arousal. (F) Stimulation-induced arousal change (score during stim – pre) as function of dorsal-ventral distance from CL center. Symbols show stimulation events by monkey; red curve shows quadratic fit (±SE). (G) Example stimulation series for different frequencies during propofol (left) and isoflurane (right) at same site 22.5 mm ventral to cortical surface. (H) Population mean arousal change (±SE of point estimate) for different stimulation frequencies at effective and ineffective sites from both monkeys.

Article Snippet: ​ REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, Peptides, and Recombinant Proteins Isoflurane, USP Piramal Enterprises Limited NDC 66794–013–25 PropoFlo 28 (Propofol) Zoetis Inc. NDC 54771–4944–1 KETAVED (KETAMINE HCL 100MG) Vedco Inc. NDC 50989–996–06 Experimental Models: Organisms/Strains Monkeys (Macaca mulatta) Wisconsin National Primate Research Center (WNPRC) https://www.primate.wisc.edu/ Software and Algorithms OmniPlex Server v 1.14.1 Plexon https://plexon.com/products/omniplex-software/ PlexContron v 1.14.1 Plexon https://plexon.com/products/omniplex-software/ Plexon Stim-2 v 2.3.0.0 Plexon https://plexon.com/products/plexstim-electrical-stimulator-2-system/ Presentation v 19.0 Neurobehavioral Systems https://www.neurobs.com/ Logitech Webcam Software v 2.51 Logitech https://support.logi.com/hc/en-us/articles/360024691274--Downloads-Webcam-C260 Fsl v 1.6 Oxford University Innovation https://fsl.fmrib.ox.ac.uk/fsldownloads_registration Fsleyes v 0.22.6 Oxford University Innovation https://fsl.fmrib.ox.ac.uk/fsldownloads_registration XQuartz v 2.7.11 X.Org Foundation https://www.xquartz.org/ Offline Sorter v4 Plexon https://plexon.com/products/offline-sorter/ Matlab R2015b MathWorks https://www.mathworks.com/products.html?s_tid=gn_ps Chronux v 2.11 chronux http://chronux.org/ SARGE toolbox v 1.5.4 IBG Lab https://www.ibglab.org/sarge CSDplotter v 0.1.1 Klas Pettersen ( on.bmu@nesrettep.salk .) https://github.com/espenhgn/CSDplotter R v 3.2.2 R Foundation for Statistical Computing https://www.r-project.org/ RStudio v 1.1.463 R Studio https://rstudio.com/ Movavi Video Converter v 7.3.0 Movavi https://www.movavi.com/videoconvertermac/?device=c&gclid=Cj0KCQiAtrnuBRDXARIsABiN-7BytoiOxcGD8lyR3Fvs1MGc3zWwA0UisQaA1DdujFHHS_q1fbZk6WwaAlnlEALw_wcB Elmedia video player v 7.6 Elmedia Player https://www.elmedia-video-player.com/ Other Macaque Stimulated Arousal Index This paper STAR methods , Email ( ude.csiw@hguabniderm ) Open in a separate window KEY RESOURCES TABLE (KRT) Central lateral thalamic stimulation arouses macaques from stable anesthesia Thalamic and deep layer cortical spiking correlate with consciousness level Consciousness depends on feedforward, feedback and intracolumnar signaling Pathway-specific signaling operates at alpha and gamma during consciousness

Techniques:

KEY RESOURCES TABLE (KRT)

Journal: Neuron

Article Title: Thalamus modulates consciousness via layer-specific control of cortex

doi: 10.1016/j.neuron.2020.01.005

Figure Lengend Snippet: KEY RESOURCES TABLE (KRT)

Article Snippet: ​ REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, Peptides, and Recombinant Proteins Isoflurane, USP Piramal Enterprises Limited NDC 66794–013–25 PropoFlo 28 (Propofol) Zoetis Inc. NDC 54771–4944–1 KETAVED (KETAMINE HCL 100MG) Vedco Inc. NDC 50989–996–06 Experimental Models: Organisms/Strains Monkeys (Macaca mulatta) Wisconsin National Primate Research Center (WNPRC) https://www.primate.wisc.edu/ Software and Algorithms OmniPlex Server v 1.14.1 Plexon https://plexon.com/products/omniplex-software/ PlexContron v 1.14.1 Plexon https://plexon.com/products/omniplex-software/ Plexon Stim-2 v 2.3.0.0 Plexon https://plexon.com/products/plexstim-electrical-stimulator-2-system/ Presentation v 19.0 Neurobehavioral Systems https://www.neurobs.com/ Logitech Webcam Software v 2.51 Logitech https://support.logi.com/hc/en-us/articles/360024691274--Downloads-Webcam-C260 Fsl v 1.6 Oxford University Innovation https://fsl.fmrib.ox.ac.uk/fsldownloads_registration Fsleyes v 0.22.6 Oxford University Innovation https://fsl.fmrib.ox.ac.uk/fsldownloads_registration XQuartz v 2.7.11 X.Org Foundation https://www.xquartz.org/ Offline Sorter v4 Plexon https://plexon.com/products/offline-sorter/ Matlab R2015b MathWorks https://www.mathworks.com/products.html?s_tid=gn_ps Chronux v 2.11 chronux http://chronux.org/ SARGE toolbox v 1.5.4 IBG Lab https://www.ibglab.org/sarge CSDplotter v 0.1.1 Klas Pettersen ( on.bmu@nesrettep.salk .) https://github.com/espenhgn/CSDplotter R v 3.2.2 R Foundation for Statistical Computing https://www.r-project.org/ RStudio v 1.1.463 R Studio https://rstudio.com/ Movavi Video Converter v 7.3.0 Movavi https://www.movavi.com/videoconvertermac/?device=c&gclid=Cj0KCQiAtrnuBRDXARIsABiN-7BytoiOxcGD8lyR3Fvs1MGc3zWwA0UisQaA1DdujFHHS_q1fbZk6WwaAlnlEALw_wcB Elmedia video player v 7.6 Elmedia Player https://www.elmedia-video-player.com/ Other Macaque Stimulated Arousal Index This paper STAR methods , Email ( ude.csiw@hguabniderm ) Open in a separate window KEY RESOURCES TABLE (KRT) Central lateral thalamic stimulation arouses macaques from stable anesthesia Thalamic and deep layer cortical spiking correlate with consciousness level Consciousness depends on feedforward, feedback and intracolumnar signaling Pathway-specific signaling operates at alpha and gamma during consciousness

Techniques: Recombinant, Software

(A) Example behavioral and neural recordings during 50 Hz stimulation (arousal score 5). (B) Population mean arousal score (±SE) before, during and after stimulations for both monkeys (circles show individual stimulation events). (C) Coronal section of right hemisphere 8mm anterior to interaural line (A8). Arrow shows electrode. (D) Zoomed-in view of thalamus. (E) Stimulation sites in monkey R (N = 90) collapsed along A-P axis. Circles represent middle contact in stimulation array; diameter scales with induced arousal. (F) Stimulation-induced arousal change (score during stim – pre) as function of dorsal-ventral distance from CL center. Symbols show stimulation events by monkey; red curve shows quadratic fit (±SE). (G) Example stimulation series for different frequencies during propofol (left) and isoflurane (right) at same site 22.5 mm ventral to cortical surface. (H) Population mean arousal change (±SE of point estimate) for different stimulation frequencies at effective and ineffective sites from both monkeys.

Journal: Neuron

Article Title: Thalamus modulates consciousness via layer-specific control of cortex

doi: 10.1016/j.neuron.2020.01.005

Figure Lengend Snippet: (A) Example behavioral and neural recordings during 50 Hz stimulation (arousal score 5). (B) Population mean arousal score (±SE) before, during and after stimulations for both monkeys (circles show individual stimulation events). (C) Coronal section of right hemisphere 8mm anterior to interaural line (A8). Arrow shows electrode. (D) Zoomed-in view of thalamus. (E) Stimulation sites in monkey R (N = 90) collapsed along A-P axis. Circles represent middle contact in stimulation array; diameter scales with induced arousal. (F) Stimulation-induced arousal change (score during stim – pre) as function of dorsal-ventral distance from CL center. Symbols show stimulation events by monkey; red curve shows quadratic fit (±SE). (G) Example stimulation series for different frequencies during propofol (left) and isoflurane (right) at same site 22.5 mm ventral to cortical surface. (H) Population mean arousal change (±SE of point estimate) for different stimulation frequencies at effective and ineffective sites from both monkeys.

Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, Peptides, and Recombinant Proteins Isoflurane, USP Piramal Enterprises Limited NDC 66794–013–25 PropoFlo 28 (Propofol) Zoetis Inc. NDC 54771–4944–1 KETAVED (KETAMINE HCL 100MG) Vedco Inc. NDC 50989–996–06 Experimental Models: Organisms/Strains Monkeys (Macaca mulatta) Wisconsin National Primate Research Center (WNPRC) https://www.primate.wisc.edu/ Software and Algorithms OmniPlex Server v 1.14.1 Plexon https://plexon.com/products/omniplex-software/ PlexContron v 1.14.1 Plexon https://plexon.com/products/omniplex-software/ Plexon Stim-2 v 2.3.0.0 Plexon https://plexon.com/products/plexstim-electrical-stimulator-2-system/ Presentation v 19.0 Neurobehavioral Systems https://www.neurobs.com/ Logitech Webcam Software v 2.51 Logitech https://support.logi.com/hc/en-us/articles/360024691274--Downloads-Webcam-C260 Fsl v 1.6 Oxford University Innovation https://fsl.fmrib.ox.ac.uk/fsldownloads_registration Fsleyes v 0.22.6 Oxford University Innovation https://fsl.fmrib.ox.ac.uk/fsldownloads_registration XQuartz v 2.7.11 X.Org Foundation https://www.xquartz.org/ Offline Sorter v4 Plexon https://plexon.com/products/offline-sorter/ Matlab R2015b MathWorks https://www.mathworks.com/products.html?s_tid=gn_ps Chronux v 2.11 chronux http://chronux.org/ SARGE toolbox v 1.5.4 IBG Lab https://www.ibglab.org/sarge CSDplotter v 0.1.1 Klas Pettersen ( on.bmu@nesrettep.salk .) https://github.com/espenhgn/CSDplotter R v 3.2.2 R Foundation for Statistical Computing https://www.r-project.org/ RStudio v 1.1.463 R Studio https://rstudio.com/ Movavi Video Converter v 7.3.0 Movavi https://www.movavi.com/videoconvertermac/?device=c&gclid=Cj0KCQiAtrnuBRDXARIsABiN-7BytoiOxcGD8lyR3Fvs1MGc3zWwA0UisQaA1DdujFHHS_q1fbZk6WwaAlnlEALw_wcB Elmedia video player v 7.6 Elmedia Player https://www.elmedia-video-player.com/ Other Macaque Stimulated Arousal Index This paper STAR methods , Email ( ude.csiw@hguabniderm ) Open in a separate window KEY RESOURCES TABLE (KRT) Central lateral thalamic stimulation arouses macaques from stable anesthesia Thalamic and deep layer cortical spiking correlate with consciousness level Consciousness depends on feedforward, feedback and intracolumnar signaling Pathway-specific signaling operates at alpha and gamma during consciousness

Techniques:

KEY RESOURCES TABLE (KRT)

Journal: Neuron

Article Title: Thalamus modulates consciousness via layer-specific control of cortex

doi: 10.1016/j.neuron.2020.01.005

Figure Lengend Snippet: KEY RESOURCES TABLE (KRT)

Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, Peptides, and Recombinant Proteins Isoflurane, USP Piramal Enterprises Limited NDC 66794–013–25 PropoFlo 28 (Propofol) Zoetis Inc. NDC 54771–4944–1 KETAVED (KETAMINE HCL 100MG) Vedco Inc. NDC 50989–996–06 Experimental Models: Organisms/Strains Monkeys (Macaca mulatta) Wisconsin National Primate Research Center (WNPRC) https://www.primate.wisc.edu/ Software and Algorithms OmniPlex Server v 1.14.1 Plexon https://plexon.com/products/omniplex-software/ PlexContron v 1.14.1 Plexon https://plexon.com/products/omniplex-software/ Plexon Stim-2 v 2.3.0.0 Plexon https://plexon.com/products/plexstim-electrical-stimulator-2-system/ Presentation v 19.0 Neurobehavioral Systems https://www.neurobs.com/ Logitech Webcam Software v 2.51 Logitech https://support.logi.com/hc/en-us/articles/360024691274--Downloads-Webcam-C260 Fsl v 1.6 Oxford University Innovation https://fsl.fmrib.ox.ac.uk/fsldownloads_registration Fsleyes v 0.22.6 Oxford University Innovation https://fsl.fmrib.ox.ac.uk/fsldownloads_registration XQuartz v 2.7.11 X.Org Foundation https://www.xquartz.org/ Offline Sorter v4 Plexon https://plexon.com/products/offline-sorter/ Matlab R2015b MathWorks https://www.mathworks.com/products.html?s_tid=gn_ps Chronux v 2.11 chronux http://chronux.org/ SARGE toolbox v 1.5.4 IBG Lab https://www.ibglab.org/sarge CSDplotter v 0.1.1 Klas Pettersen ( on.bmu@nesrettep.salk .) https://github.com/espenhgn/CSDplotter R v 3.2.2 R Foundation for Statistical Computing https://www.r-project.org/ RStudio v 1.1.463 R Studio https://rstudio.com/ Movavi Video Converter v 7.3.0 Movavi https://www.movavi.com/videoconvertermac/?device=c&gclid=Cj0KCQiAtrnuBRDXARIsABiN-7BytoiOxcGD8lyR3Fvs1MGc3zWwA0UisQaA1DdujFHHS_q1fbZk6WwaAlnlEALw_wcB Elmedia video player v 7.6 Elmedia Player https://www.elmedia-video-player.com/ Other Macaque Stimulated Arousal Index This paper STAR methods , Email ( ude.csiw@hguabniderm ) Open in a separate window KEY RESOURCES TABLE (KRT) Central lateral thalamic stimulation arouses macaques from stable anesthesia Thalamic and deep layer cortical spiking correlate with consciousness level Consciousness depends on feedforward, feedback and intracolumnar signaling Pathway-specific signaling operates at alpha and gamma during consciousness

Techniques: Recombinant, Software